1. Avoid exposure to allergen
2. In excessive nasal secretions (Rinorrhea,sneezing,itching):

• Histazin 5mg/5ml syrup 2-5ml  daily in 1 or 2 divided doses

3. In nasal obstruction:

• Apisal 9mg/ml drop 1drop 4-6 times daily

Promethazine

Available forms:

• Histazin : 5mg/5ml syrup, 25mg tab
• Promet: 25mg tab
• Promethazine: 50mg/2ml for iv,im injection 

Therapeutic indications

• As symptomatic treatment for allergic conditions of the upper respiratory tract and skin including allergic rhinitis, urticaria and anaphylactic reactions to drugs and foreign proteins.
• As an antiemetic.
• For short term use in treatment of insomnia in adults.
• For short term use as a paediatric sedative.

The usual doses are:

25mg tablet:

• Adults  and Children>10 years : Start with 1 tablet (25 mg) taken at night. This maybe increased to a maximum of 1 tablet (25 mg) twice a dayif necessary.
• Children 5-10 years: A single tablet (25 mg) given at night. DO NOT give more than 25 mg per day.

50mg/2ml for iv,im injection 

• Adult : 25 mg; may be repeated in 2 hours when necessary; switch to PO as soon as possible
• Pediatrics≥2 years: 12.5-25 mg IM at bedtime

5mg/5ml syrup:

• 2-5 years: 5-15 mg(1-3ml) daily in 1 or 2 divided doses
• >5-10 years : 10-25(2-5ml) mg daily in 1 or 2 divided doses

Contraindications

• should not be used in patients in coma or suffering from CNS depression of any cause.
• should not be given to patients with a known hypersensitivity to any of the excipients.
• contraindicated for use in children less than two years of age because of the potential for fatal respiratory depression..

pregnancy and lactation

• should not be used in pregnancy unless the physician considers it essential.
• The use is not recommended in the 2 weeks prior to delivery in view of the risk of irritability and excitement in the neonate.
• Available evidence suggests that the amount excreted in milk is insignificant. However, there are risks of neonatal irritability and excitement.

Side effects 

• drowsiness, dizziness, restlessness, headaches, nightmares, tiredness, and disorientation. blurred vision, dry mouth and urinary retention 

Apisal 9mg/ml drop, 7.4mg/ml spray

• Nasal decongestant
• is a safe drug-free physiological saline solution
• can be used as often as needed, to cleanse and moisturize nasal passages and help in removing incrustations, bacteria, viruses, allergens or irritants entrapped in the nasal mucosa.
• Nasal Dryness & Congestion
• relieves nasal congestion by thinning mucus and moisturizes membranes

Dose in adult and pediatrics:

• 1puffs /drop 4-6 times daily

Pregnancy and lactation:

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