1. Azithromycin 500mg capsule  on first day then 250mg capsules orally 1×1 on Days 2-5
2. Brufen 400mg tablet +  Paracetamol ( Revenin)500mg tablets  alternately every 4-6       hours until fever subside
3. Gurgle with salt and water solution (don’t swallow it ) 3 times daily
4. Soft food and warm drinks

Azithromycin 

Dosage Forms & Strengths:

• 250mg ,500mg  capsule and tablet, 500mg vial, 200mg/5ml suspension, 300mg /7.5ml suspension

Trade names  :

Zocin, Zimax , Zomax, Azomycin, Azi_once, Zithromax, Azitam, Zithrova, Zaha, Zilacid, Azicure, Azomyne , Azox

Therapeutic indication and dose :

Community-acquired Pneumonia

• 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5

Pharyngitis or Tonsillitis

• 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5

Uncomplicated skin/skin structure

• 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5

Acute bacterial exacerbations of chronic obstructive pulmonary disease

• 500 mg PO qDay for 3 days OR
• 500 mg PO x 1 dose on Day 1, followed by 250 mg PO qDay on Days 2-5

Acute bacterial sinusitis

• 500 mg PO qDay x 3 days

Genital Ulcer Disease (Chancroid)

• 1000 mg PO x 1 dose

Nongonococcal or Gonococcal Urethritis and Cervicitis

• 1000 mg PO x 1 dose

Cat Scratch Disease (Off-label)

• >45.5 kg: 500 mg PO once, then 250 mg once daily for 4 days

Pertussis (Off-label)

• 500 mg PO once, then 250 mg once daily for 4 days

Endocarditis (Off-label)

Prophylaxis

• 500 mg PO 30-60 min before procedure

Contraindications:

• Hypersensitivity to azithromycin, erythromycin, any macrolide

Pregnancy:

• The safety of azithromycin has not been confirmed with regard to the use of the active substance during pregnancy. Therefore, Azithromycin should only be used during pregnancy if the benefit outweighs the risk

Breastfeeding :

• Azithromycin has been reported to be secreted into human breast milk
• Because it is not known whether azithromycin may have adverse effects on the breast-fed infant, nursing should be discontinued during treatment with Azithromycin. Among other things diarrhea, fungus infection of the mucous membrane is possible in the nursed infant. It is recommended to discard the milk during treatment and up until 2 days after discontinuation of treatment. Nursing may be resumed thereafter. 

Common side effects:

• Anorexia
• Dizziness, headache, paranesthesia, dysgeusia
• Visual impairment, Deafness
• Vomiting, dyspepsia
• Rash, pruritus

Brufen

• Analgesic and antipyretics
• Has anti-inflammatory effect
• Suitable for Temperature( 38-38.5) C
• Not save under 6 months
• Taken After meal
  • 200mg every 6-8 hours, May increase to 400mg every 6-8hours 

Trade names :  brufen (Taskine , Doloraz, Iburam,Remofen , Ibugesic, Sapofen, Perofen, Rupan,Bulkaprofen, Advil liquid-gel , Profast, Nashat ,Midofen, Ibusoft).

Other concentration: 800mg and 400mg tablet 600mg tablet, 100mg/5ml syrup

Dose:

Tablets :

Syrup, suspension :

• 100mg/5ml Syrup(Wx0.375) every 6-8hours

Oral drops :

40mg/1ml 

• 6-11 months  : 1.25ml every 8 hours
• 12-23months : 1.8ml every 8 hours

Maximum dose : 3200 mg per day  

Contraindication: 

• History of hypersensitivity to aspirin or other NSAIDs
• current or recent stomach ulcer
• severe heart failure.
• severe liver disease

Pregnancy : not usually recommended in pregnancy

Paractamol

• Analgesic and antipyretics
• Not anti-inflammatory effect
• Suitable for Temperature between (37.5C – 38.5C)
• Safe under 6 months

Trade names  : ( Revanin ,Adol,Panda,Dolocet ,Feverol, panadol )

Concentrations: 500 mg tablet, ,1g tablet ,125 mg/5 ml syrup, 250 mg/5 ml syrup, 125 mg suppositories, 250 mg suppositories, 1g/100ml solution for infusion

Dose : 

Tablet, capsule : 

• 500mg tabs 1-2 tabs /cap every 6 hours

Syrup, suspension :

• < 5year  : 125mg/5ml susp (w/2) Every 4 – 6 hours
• 5-12 year : 250mg/5ml susp (w/4) Every 4 – 6 hours 

Suppositories :

• <1Y : 125 mg supp Every 8 hours  (1 supp x 3 )
• >1Y : 250mg supp Every 8 hours ( 1supp x 3 )

Iv solution 1g/100ml :

• <10kg : 0 .75ml/kg 
• >10kg , <50kg :  1.5ml/kg
• >50kg : 100ml Slowly over 15 minute

Maximum dose : 4g daily 

Pregnancy and lactation : Paracetamol is the first choice of painkiller in pregnancy and breastfeeding